Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.
Identifieur interne : 000303 ( Main/Exploration ); précédent : 000302; suivant : 000304Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.
Auteurs : Silvia Rizzi ; Maarten Jan Wensink ; Rune Lindahl-Jacobsen ; Lu Tian ; Ying Lu ; Michael EisenbergSource :
- Research square ; 2020.
Abstract
OBJECTIVE
With the ongoing COVID-19 pandemic, large numbers of people will receive one of the several medications proposed to treat COVID-19, including patients of reproductive age. Given that some medications have shown adverse effects on sperm quality, there might be a transgenerational concern. We aim at examining the association between drugs proposed to treat COVID-19 when taken by the father around conception and any pre-term birth or major birth defects in offspring in a nation-wide cohort study using Danish registry data. Offspring whose father filled at least one prescription of the following medications in the three months preceding conception were considered exposed: chloroquine, hydroxychloroquine, losartan, azithromycin, naproxen, dexamethasone and prednisone.
RESULTS
For azithromycin and naproxen, large numbers of offspring were exposed (> 1800 offspring), and we found no association with adverse birth outcomes. For chloroquine, losartan and dexamethasone, exposure was intermediate (~ 900 offspring), and there was no statistically significant association with birth defects. For hydroxychloroquine and prednisone, exposure was limited (< 300 offspring). There is strong evidence that azithromycin and naproxen are safe with respect to pre-term birth and birth defects. With some caution, the other drugs investigated can be considered safe.
DOI: 10.21203/rs.3.rs-59420/v1
PubMed: 32869015
PubMed Central: PMC7457584
Affiliations:
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sortKey="Lindahl Jacobsen, Rune" sort="Lindahl Jacobsen, Rune" uniqKey="Lindahl Jacobsen R" first="Rune" last="Lindahl-Jacobsen">Rune Lindahl-Jacobsen</name><affiliation><nlm:affiliation>Syddansk Universitet.</nlm:affiliation><wicri:noCountry code="no comma">Syddansk Universitet.</wicri:noCountry><wicri:noCountry code="no comma">Syddansk Universitet.</wicri:noCountry></affiliation></author><author><name sortKey="Tian, Lu" sort="Tian, Lu" uniqKey="Tian L" first="Lu" last="Tian">Lu Tian</name><affiliation><nlm:affiliation>Stanford University School of Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Lu, Ying" sort="Lu, Ying" uniqKey="Lu Y" first="Ying" last="Lu">Ying Lu</name><affiliation><nlm:affiliation>Stanford University School of Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Eisenberg, Michael" sort="Eisenberg, Michael" uniqKey="Eisenberg M" first="Michael" last="Eisenberg">Michael Eisenberg</name><affiliation><nlm:affiliation>Stanford University School of Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32869015</idno><idno type="pmid">32869015</idno><idno type="doi">10.21203/rs.3.rs-59420/v1</idno><idno type="pmc">PMC7457584</idno><idno type="wicri:Area/Main/Corpus">000362</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" 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Wensink</name><affiliation><nlm:affiliation>Syddansk Universitet.</nlm:affiliation><wicri:noCountry code="no comma">Syddansk Universitet.</wicri:noCountry><wicri:noCountry code="no comma">Syddansk Universitet.</wicri:noCountry></affiliation></author><author><name sortKey="Lindahl Jacobsen, Rune" sort="Lindahl Jacobsen, Rune" uniqKey="Lindahl Jacobsen R" first="Rune" last="Lindahl-Jacobsen">Rune Lindahl-Jacobsen</name><affiliation><nlm:affiliation>Syddansk Universitet.</nlm:affiliation><wicri:noCountry code="no comma">Syddansk Universitet.</wicri:noCountry><wicri:noCountry code="no comma">Syddansk Universitet.</wicri:noCountry></affiliation></author><author><name sortKey="Tian, Lu" sort="Tian, Lu" uniqKey="Tian L" first="Lu" last="Tian">Lu Tian</name><affiliation><nlm:affiliation>Stanford University School of Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Lu, Ying" sort="Lu, Ying" uniqKey="Lu Y" first="Ying" last="Lu">Ying Lu</name><affiliation><nlm:affiliation>Stanford University School of Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Eisenberg, Michael" sort="Eisenberg, Michael" uniqKey="Eisenberg M" first="Michael" last="Eisenberg">Michael Eisenberg</name><affiliation><nlm:affiliation>Stanford University School of Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Stanford University School of Medicine.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Research square</title><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>With the ongoing COVID-19 pandemic, large numbers of people will receive one of the several medications proposed to treat COVID-19, including patients of reproductive age. Given that some medications have shown adverse effects on sperm quality, there might be a transgenerational concern. We aim at examining the association between drugs proposed to treat COVID-19 when taken by the father around conception and any pre-term birth or major birth defects in offspring in a nation-wide cohort study using Danish registry data. Offspring whose father filled at least one prescription of the following medications in the three months preceding conception were considered exposed: chloroquine, hydroxychloroquine, losartan, azithromycin, naproxen, dexamethasone and prednisone.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>For azithromycin and naproxen, large numbers of offspring were exposed (> 1800 offspring), and we found no association with adverse birth outcomes. For chloroquine, losartan and dexamethasone, exposure was intermediate (~ 900 offspring), and there was no statistically significant association with birth defects. For hydroxychloroquine and prednisone, exposure was limited (< 300 offspring). There is strong evidence that azithromycin and naproxen are safe with respect to pre-term birth and birth defects. With some caution, the other drugs investigated can be considered safe.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32869015</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>10</Day></DateRevised><Article PubModel="Electronic"><Journal><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>26</Day></PubDate></JournalIssue><Title>Research square</Title><ISOAbbreviation>Res Sq</ISOAbbreviation></Journal><ArticleTitle>Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">rs.3.rs-59420</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.21203/rs.3.rs-59420/v1</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">With the ongoing COVID-19 pandemic, large numbers of people will receive one of the several medications proposed to treat COVID-19, including patients of reproductive age. Given that some medications have shown adverse effects on sperm quality, there might be a transgenerational concern. We aim at examining the association between drugs proposed to treat COVID-19 when taken by the father around conception and any pre-term birth or major birth defects in offspring in a nation-wide cohort study using Danish registry data. Offspring whose father filled at least one prescription of the following medications in the three months preceding conception were considered exposed: chloroquine, hydroxychloroquine, losartan, azithromycin, naproxen, dexamethasone and prednisone.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">For azithromycin and naproxen, large numbers of offspring were exposed (> 1800 offspring), and we found no association with adverse birth outcomes. For chloroquine, losartan and dexamethasone, exposure was intermediate (~ 900 offspring), and there was no statistically significant association with birth defects. For hydroxychloroquine and prednisone, exposure was limited (< 300 offspring). There is strong evidence that azithromycin and naproxen are safe with respect to pre-term birth and birth defects. 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ValidYN="Y"><LastName>Lu</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Stanford University School of Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eisenberg</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Stanford University School of Medicine.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R21 HD096468</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR003142</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D000076942">Preprint</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United 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sort="Tian, Lu" uniqKey="Tian L" first="Lu" last="Tian">Lu Tian</name><name sortKey="Wensink, Maarten Jan" sort="Wensink, Maarten Jan" uniqKey="Wensink M" first="Maarten Jan" last="Wensink">Maarten Jan Wensink</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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